A CRITICAL REVIEW ON PHARMACOLOGICAL AND MECHANICAL PROPERTIES OF DAIDZEIN
DOI:
https://doi.org/10.47413/vidya.v1i1.32Keywords:
Anti-cancer, Anti-inflammatory, Daidzein, Flavonoids, PhytoestrogenAbstract
Medicinal plants have proved to be of great importance since long back as they are traditionally used to make plant-derived medicines that are a good alternative to synthetic chemicals. Daidzein is one such chemical compound that belongs to the group of isoflavones and is obtained from leguminous plants, especially soy plants. Daidzein is structurally similar to human hormone estrogen due to which is also called a phytoestrogen. Daidzein is an isoflavone compound that is mostly found in glycosylated form in plants while in humans it is found in free form in the bloodstream. It is clinically used in treatment of variety of cancers. It has become quite successful in treating ovarian cancer, breast cancer, and thyroid cancer. Daidzein also possess some exquisite properties such as anti-inflammatory properties, anti-oxidant properties, and neuroprotective properties. In this paper mechanical properties of daidzein are also discussed in which daidzein has been proved as an excellent wood adhesive agent for industrial purpose. Also, daidzein is used as flame retardant and is doing good in dietary supplementations. Daidzein can be important for further pharmaceutical and industrial applications.
References
Adjakly, M., Ngollo, M., Boiteux, J. P., Bignon, Y. J., Guy, L., & Bernard-Gallon, D. (2013). Genistein and daidzein: different molecular effects on prostate cancer. Anticancer research, 33(1), 39-44.
Baechler, S. A., Schroeter, A., Walker, J., Aichinger, G., & Marko, D. (2014). Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein. Molecular nutrition & food research, 58(6), 1269-1281.
Choi, E. J., & Kim, G. H. (2013). Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells. Molecular Medicine Reports, 7(3), 781-784.
Choi, E. J., & Kim, G. H. (2014). The antioxidant activity of daidzein metabolites, O desmethylangolensin and equol, in HepG2 cells. Molecular medicine reports, 9(1), 328-332.
Choi, E. Y., Jin, J. Y., Lee, J. Y., Choi, J. I., Choi, I. S., & Kim, S. J. (2012). Anti‐inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. Journal of periodontal research, 47(2), 204-211.
Choi, R. C., Zhu, J. T., Yung, A. W., Lee, P. S., Xu, S. L., Guo, A. J., ... & Tsim, K. W. (2013). Synergistic action of flavonoids, baicalein, and daidzein in estrogenic and neuroprotective effects: a development of potential health products and therapeutic drugs against Alzheimer’s disease. Evidence-Based Complementary and Alternative Medicine, 2013. Article ID 635694
Dai, J., Teng, N., Peng, Y., Liu, Y., Cao, L., Zhu, J., & Liu, X. (2018). Biobased Benzoxazine Derived from Daidzein and Furfurylamine: Microwave‐Assisted Synthesis and Thermal Properties Investigation. ChemSusChem, 11(18), 3175-3183.
Di Virgilio, A. L., Iwami, K., Wätjen, W., Kahl, R., & Degen, G. H. (2004). Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology letters, 151(1), 151-162.
Dwiecki, K., Neunert, G., Polewski, P., & Polewski, K. (2009). Antioxidant activity of daidzein, a natural antioxidant, and its spectroscopic properties in organic solvents and phosphatidylcholine liposomes. Journal of Photochemistry and Photobiology B: Biology, 96(3), 242-248.
Han, M., You, S., Wang, Y., Zhang, K., & Yang, S. (2019). Synthesis of highly thermally stable daidzein-based main-chain-type benzoxazine resins. Polymers, 11(8), 1341.
Heinonen, S. M., Hoikkala, A., Wähälä, K., & Adlercreutz, H. (2003). Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects.: Identification of new metabolites having an intact isoflavonoid skeleton. The Journal of steroid biochemistry and molecular biology, 87(4-5), 285-299.
Hua, F., Li, C. H., Chen, X. G., & Liu, X. P. (2018). Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade. International Journal of Molecular Medicine, 41(6), 3485-3492.
Jiao, Y., Peng, J., Ye, X., Hu, H., Gan, L., Yang, J., & Peng, Y. Study on pharmacological properties and cell absorption metabolism of novel daidzein napsylates. Royal Society Open Science, 8(1), 201475.
Jin, S., Zhang, Q. Y., Kang, X. M., Wang, J. X., & Zhao, W. H. (2010). Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Annals of Oncology, 21(2), 263-268.
Kim, K. M., Park, J. S., Choi, H., Kim, M. S., Seo, J. H., Pandey, R. P., ... & Kim, S. Y. (2018). Biosynthesis of novel daidzein derivatives using Bacillus amyloliquefaciens whole cells. Biocatalysis and Biotransformation, 36(6), 469-475.
Kim, M. H., Han, J. H., & Kim, S. U. (2008). Isoflavone daidzein: chemistry and bacterial metabolism. Journal of Applied Biological Chemistry, 51(6), 253-261.
Li, Y., Li, Y., Gao, J., Wang, L., Zou, L., & Ye, B. (2015). A novel strategy of electrochemically treated ZrOCl2 doped carbon paste electrode for sensitive determination of daidzein. Electroanalysis, 27(7), 1719-1725.
Liang, J., Tian, Y. X., Fu, L. M., Wang, T. H., Li, H. J., Wang, P., ... & Skibsted, L. H. (2008). Daidzein as an antioxidant of lipid: Effects of the microenvironment in relation to chemical structure. Journal of agricultural and food chemistry, 56(21), 10376-10383.
Liu, X., Suzuki, N., Laxmi, Y. S., Okamoto, Y., & Shibutani, S. (2012). Anti-breast cancer potential of daidzein in rodents. Life sciences, 91(11-12), 415-419.
Lu, Z., Zhou, R., Kong, Y., Wang, J., Xia, W., Guo, J., ... & Xu, H. (2016). S-equol, a secondary metabolite of natural anticancer isoflavone daidzein, inhibits prostate cancer growth in vitro and in vivo, though activating the Akt/FOXO3a pathway. Current cancer drug targets, 16(5), 455-465.
Ma, C., & Li, J. (2019). Synthesis of an organophosphorus flame retardant derived from daidzein and its application in epoxy resin. Composites Part B: Engineering, 178, 107471.
Meng, H., Fu, G., Shen, J., Shen, K., Xu, Z., Wang, Y., ... & Pan, H. (2017). Ameliorative effect of daidzein on cisplatin-induced nephrotoxicity in mice via modulation of inflammation, oxidative stress, and cell death. Oxidative Medicine and Cellular Longevity, 2017. Article ID 3140680.
Morelli, S., Piscioneri, A., Guarnieri, G., Morelli, A., Drioli, E., & De Bartolo, L. (2020). Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model. BioFactors, 47, 93-111.
Peng, Y., Shi, Y., Zhang, H., Mine, Y., & Tsao, R. (2017). Anti-inflammatory and anti-oxidative activities of daidzein and its sulfonic acid ester derivatives. Journal of Functional Foods, 35, 635-640.
Romano, B., Lucariello, G., & Capasso, R. (2021). Topical Collection “Pharmacology of Medicinal Plants”. Biomolecules, 11(1), 101.
Somjen, D., Grafi-Cohen, M., Katzburg, S., Weisinger, G., Izkhakov, E., Nevo, N., ... & Stern, N. (2011). Anti-thyroid cancer properties of a novel isoflavone derivative, 7-(O)-carboxymethyl daidzein conjugated to Nt-Boc-hexylenediamine in vitro and in vivo. The Journal of steroid biochemistry and molecular biology, 126(3-5), 95-103.
Soukup, S. T., Helppi, J., Müller, D. R., Zierau, O., Watzl, B., Vollmer, G., ... & Kulling, S. E. (2016). Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison. Archives of toxicology, 90(6), 1335-1347.
Sun, M. Y., Ye, Y., Xiao, L., Rahman, K., Xia, W., & Zhang, H. (2016). Daidzein: A review of pharmacological effects. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 117-132.
Van Wyk, B. E., & Wink, M. (2018). Medicinal plants of the world. Nosworthy, Wallingford, UK, CABI.
Xiao, Y. Q., Shao, D., Sheng, Z. W., Wang, Q., & Shi, S. R. (2019). A mixture of daidzein and Chinese herbs increases egg production and eggshell strength as well as blood plasma Ca, P, antioxidative enzymes, and luteinizing hormone levels in post-peak, brown laying hens. Poultry science, 98(8), 3298-3303.
Xu, C., Xu, Y., Chen, M., Zhang, Y., Li, J., Gao, Q., & Shi, S. Q. (2020). Soy protein adhesive with bio-based epoxidized daidzein for high strength and mildew resistance. Chemical Engineering Journal, 390, 124622.
Yang, Y., Yang, X., Zhang, Y., Zhou, H., Zhang, J., Xu, L., & Ding, Z. (2013). A new daidzein derivative from endophytic Streptomyces sp. YIM 65408. Natural Product Research, 27(19), 1727-1731.
Yasuda, T., Kano, Y., Saito, K. I., & Ohsawa, K. (1994). Urinary and biliary metabolites of daidzin and daidzein in rats. Biological and Pharmaceutical Bulletin, 17(10), 1369-1374.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 VIDYA - A JOURNAL OF GUJARAT UNIVERSITY
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
